Peirce A. Side effects generally occurred within the first few days of adding these supplements to their diet. Insomnia 12. This result could be explained by the neuroprotective components contained in C. vulgaris (linoleic acid and vitamin B12/methylcobalamin), which have been reported to improve depressive symptoms [51]. Immunomodulation by a unicellular green algae (Chlorella pyrenoidosa) in tumor-bearing mice. Nutr Res. Life Support.Biosph.Sci 1994;1(2):69-70. Flatulence 2. J Nutr 1997;127:378,380. No clinical evidence supports the use of Chlorella for any of the conditions listed in this section. Some people who take sun chlorella may suffer from gastrointestinal problems including gas, abdominal pain, nausea, diarrhea and/or constipation. All information will be used in a manner consistent with the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter. Some people with fibromyalgia say they feel better when they take chlorella tablets plus a liquid extract containing malic acid daily for 2 months. In a study of 35 pregnant women, taking C. pyrenoidosa tablets for 6 months during pregnancy reduced the transfer of dioxins to children through breast milk [25]. Dioxins are highly toxic, cancer-causing chemicals. Lipid extract of C. sorokiniana improved memory in rats by increasing noradrenaline and serotonin content in the hippocampus [67]. View abstract. Clinical trials are needed to investigate the potential anticancer effects of Chlorella. Miyazawa Y, Murayama T, Ooya N, et al. Therefore, increased telomerase activity boosts telomere production and increases the lifespan of cells [63, 64]. Some species of this microalga have myriad health benefits while being packed with essential nutrients [1, 2]. Contact your doctor or pharmacist if you notice any other side effects. Dizziness 7. Ohtake, T., Negishi, K., Okamoto, K., Oka, M., Maesato, K., Moriya, H., and Kobayashi, S. Manganese-induced Parkinsonism in a patient undergoing maintenance hemodialysis. Well this is actually the opposite. Tyml R. Present state and possibilities of the medical use of chlorococcal algae. Higher levels of IgA in breast milk helps reduce the risk of infection in nursing infants [25]. A 14-day study performed in 10 individuals revealed that Chlorella increased aerobic endurance capacity by improving maximum oxygen uptake [48]. One user experienced severe digestive discomfort which they think was caused by too strong detox process. This information may not fit your specific health circumstances. View abstract. Several compounds are present in Chlorella that makes it act as an antioxidant. C. vulgaris may have an anti-aging effect because it [61]: Cells age when the telomeres (ends of chromosomes) are shortened. Taken together, the effects of Chlorella on blood sugar, cholesterol, and blood pressure indicate its potential to prevent heart disease, but clinical trials should investigate this further. Chlorella comes in various forms from tiny tablets, capsules, powder to … Halperin SA, Smith B, Nolan C, et al. Honek, L., Uzel, R., Fialova, L., and Sracek, J. Due to its high concentration of protein (50%), Chlorella is a good source of the essential amino acids required for our nutrition [6]. Intense exercise can weaken the immune system. Konishi F, Tanaka K, Himeno K, et al. C. vulgaris improved the condition of lead-exposed mice by increasing their levels of white blood cells (NK cells), IFNy, IL-1a, and TNF-a, and preventing a decrease in zinc bone concentrations [45]. Depression. Ng TP, Tan WC, Lee YK. Written by Carole Beck on December 6, 2018 Reviewed … They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . Find out exactly which supplements he takes and what lifestyle changes Joe has made to maintain optimal health and prepare his body to fight off infections. Chlorella supplements aren’t approved for cancer prevention or treatment. Animal and Cellular Research (Lacking Evidence): Joe Cohen won the genetic lottery of bad genes. Warfarin (Coumadin) interacts with CHLORELLA. The researchers also found that the chlorella resulted in no negative side effects among the patients. World J Gastroenterol 2013;19(7):1085-90.View abstract. 2002;2(4):579-589. Selfhacked LLC does not provide medical advice, diagnosis, or treatment. In mice, C. vulgaris prevented psychological stress by suppressing the increase in serum corticosterone levels (a mouse analog of cortisol) [73]. Cesk.Gynekol. Another study suggested that some Chlorella extracts have an inhibitory effect on Propionibacterium acnes, a bacterium that has been described as one of the major causes of acne [77]. People respond differently to diets and supplements because everyone has unique DNA. Phytochemistry 1995;40:1433-7. CONDITIONS OF USE AND IMPORTANT INFORMATION: It may also increase sun sensitivity, especially for those with fair skin. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Chlorella improved the elimination of radioactive strontium from mice through adsorption in the intestines [43]. Below is a summary of up-to-date animal studies, cell-based research, or low-quality clinical trials which should spark further investigation. (check all that apply). Side Effects of Chlorella ♦ Some people are known to suffer from stomach problems, diarrhea, water retention, flatulence, green discoloration of stool, and nausea. Hepatogastroenterology 2012;59(119):2099-103. Stomach cramps. View abstract. In the US, you may report side effects to the FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Tiberg, E., Rolfsen, W., Einarsson, R., and Dreborg, S. Detection of Chlorella-specific IgE in mould-sensitized children. Ruama AL, Torronen R, Hanninen O, Mykkanen H. Vitamin B12 status of long-term adherents of a strict uncooked vegan diet ("living food diet") is compromised. A randomized controlled trial of 6-week Chlorella vulgaris supplementation in patients with major depressive disorder. In a placebo-controlled study with 57 borderline diabetic patients, Chlorella tablets for 12 weeks alleviated some features of type 2 diabetes by decreasing resistin production and increasing adiponectin receptor (ADIPOR1) [15]. The most common side effects include diarrhea, nausea, gas (flatulence), green discoloration of the stools, and stomach cramping, especially in the two weeks of use. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. However, one person also experienced severe nausea and vomiting after a few weeks of Chlorella supplementation. Ng, T. P., Tan, W. C., and Lee, Y. K. Occupational asthma in a pharmacist induced by Chlorella, a unicellular algae preparation. Photo: How do you avoid Chlorella side effects..? Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. Some people may experience uncomfortable side effects after ingesting even a small amount of these plants – while others breeze through the detox without so much as a headache. In rats, Chlorella promoted dioxins excretion into feces by inhibiting the absorption of dioxins from the digestive tract [39, 40]. Back To TOC. View abstract. Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others. Resp Med 1994;88:555-7. In East Asia, it is ingested with rice, tea, and pancakes. So you read the title and see the words “side effects” and I bet you are thinking that this is going to be about how spirulina is bad for your liver. Another user was building up from 1 to 5 tablets per day and reported good detox results with no side effects. They should guide further investigation but shouldn’t be interpreted as supportive of the anticancer effects until more research is done. Further research is needed to investigate the potential antidepressant effects of Chlorella. View abstract. Today, Chlorella is being used in Japan, the USA, Europe, and other countries. Constipation 4. In Canada, you may report side effects to Health Canada at 1-866-234-2345. Where did you or where do you plan to purchase this product? It can cause kidney injury in people who are allergic [83, 84]. View abstract. In a mouse model of Parkinson’s, polysaccharides from C. pyrenoidosa prevented the loss of dopamine and neuron death, inhibited inflammation, improved symptoms, and delayed disease progression [80]. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. Although superoxide dismutase (SOD) is an antioxidant enzyme, it produces hydrogen peroxide that has to be removed by GPx and catalase. This survey is being conducted by the WebMD marketing sciences department. A trial of 6 individuals revealed that Chlorella consumed for 2 weeks decreased urine levels of a cancer-causing heterocyclic amine [37]. Phytother Res 1990;4:220-31. [The use of a fresh-water weed Chlorella vulgaris for the treatment of the cervix after kryo-surgical interventions (author's transl)]. SelfDecode does not endorse any specific product, service, or treatment. However, in one study, C. vulgaris was unable to increase cadmium excretion in rats fed this heavy metal [46]. Chlorella’s principal components are [8, 5, 9]: Lycopene isolated from Chlorella marina lowered inflammatory enzymes (COX, LOX, and MPO), improved inflammatory blood markers (CRP), and markedly decreased swelling in the paw and joints of rats with arthritis. No valid clinical evidence supports the use of Chlorella for any of the conditions in this section. Swelling (inflammation) of the liver caused by the hepatitis C virus (hepatitis C). Kralovec, J. C. vulgaris enhanced cell-mediated immunity (Th1 response) in mice allergic to casein. View abstract. Uncontrolled Blood Sugar: How Dangerous Is It? Chlorella is likely safe for a general population. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. New phytophotodermatosis. Note that each number in parentheses [1, 2, 3, etc.] Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets. (2008) ^ a b Merchant RE, Carmack CA, Wise CM. A study in pregnant mice revealed how C. pyrenoidosa suppressed methylmercury transfer to the fetus and reduced its accumulation in the mothers’ brains [44]. Side effects of chlorella include: Allergic reactions, including asthma and other breathing problems Skin sensitivity to sunlight ( photosensitivity) Diarrhea Nausea Gas ( flatulence) Green discoloration of the stools Stomach cramping (especially in the first week of use) It decreased IgE levels in the blood and increased cytokines that mitigate allergies (IL-12 and IFN-gamma) [53]. Nausea and vomiting 2. Lycopene extracted from Chlorella (C. marina) suppressed the growth and induced the cell death of human prostate cancer cells [59]. Nutrigenomic studies of effects of Chlorella on subjects with high-risk factors for lifestyle-related disease. Chlorella improved atopic dermatitis symptoms in mice by [78]: Chlorella extract improved skin reconstitution and accelerated wound healing when given to wounded mice at high doses (orally and topically) [79]. These are even more likely with a higher dosage or when you first include them in your diet. J Nutr 1995;125:2511-5. Dietary Chlorella pyrenoidosa for patients with malignant glioma: effects on immunocompetence, quality of life, and survival. Azocar J, Diaz A. Efficacy and safety of chlorella supplementation in adults with chronic hepatitis C virus infection. However, you shouldn’t interpret them as supportive of any health benefit. Always consult your doctor before supplementing and let them know about all drugs and supplements you are using or considering. Some algae are potentially adequate sources of vitamin B-12 for vegans (letter, comment). Phytother Res 2000;14:167-73. Since chlorella also contains iodine, it can cause reactions in people with iodine sensitivity. ^ a b Nakashima Y, et al. Early research shows that taking chlorella for 4 weeks doesn't seem to reduce fatigue after exercise or during rest. In rats, Chlorella extracts protected against alcohol- and toxin-induced liver damage [35, 36]. Save my name, email, and website in this browser for the next time I comment. Rinsho Shinkeigaku 1995;35(7):806-807. The Sun Chlorella powder-supplement is said to have many health benefits. Vision problems 11. In this article, we are going to discuss the health benefits of chlorella for liver detoxification. Another species of Chlorella (C. sorokiniana), killed human lung cancer cells and reduced tumor growth in mice (by decreasing cell-survival factors Bcl-2, survivin, and XIAP, and increasing cell death causing Bax) [56]. But in many cases, headache, joint pain, brain fog etc. Diarrhea Most of these side effects tend to resolve as your body adapts to treatment. is a clickable link to peer-reviewed scientific studies. Detoxification. Yavasoglu I, Turgutkaya A, Bolaman Z. Chlorella-induced thrombocytopenia. Hot water extract of C. vulgaris triggered the death of human liver cancer cells by increasing p53, Bax, and caspase-3. As with any other supplement or medication, the mind’s first adverse effect is due to an allergy. View abstract. Although it was beneficial for decreasing heart disease risk factors and fat cell size, there was no significant evidence that it could help with weight loss [13]. High levels of cholesterol or other fats (lipids) in the blood (, Build up of fat in the liver in people who drink little or no alcohol (nonalcoholic. This may be a consequence of the expression of diverse cytokines that promote tumor growth (IFNy and IL-4 were decreased, while TGFβ1, IL-10, and IL-1b were increased) [60]. Panahi Y, Ghamarchehreh ME, Beiraghdar F, Zare R, Jalalian HR, Sahebkar A. Hearing problems 10. By increasing the immune system, chlorella might decrease the effectiveness of medications that are used to decrease the immune system. Eur J Obstet Gynecol Reprod Biol 2018;229:185-9. Medications that decrease the immune system (Immunosuppressants) interacts with CHLORELLA. Ichimura, S. [Effect of chlorella on skin cancer of Black Foot patients in south Formosa]. View abstract. Headaches 6. SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. Anti-tumor-promoting glyceroglycolipids from the green alga, Chlorella vulgaris. If you are worried about the side effects of doing a heavy metal detox using supplements such as cilantro and chlorella, you are not alone. Lee IT, Lee WJ, Tsai CM, Su IJ, Yen HT, Sheu WH. Functions as an Antioxidant. Itching and rash 13. Cheng, F. C., Lin, A., Feng, J. J., Mizoguchi, T., Takekoshi, H., Kubota, H., Kato, Y., and Naoki, Y. View abstract. It protected rats against cadmium liver toxicity by decreasing cadmium accumulation and stimulating the expression of metallothioneins in the liver. To their diet oxygen uptake [ 48 ] Chlorella as well 2 days of adding these to... Consequently decreased tissue levels of a Chlorella-derived dietary supplement in healthy men to diets supplements. Warfarin, by decreasing oxidative stress and inflammation [ 66 ] increasing p53,,... Do not aim to diagnose, treat, cure or prevent any or... [ 43 ] [ 33 ] or ultrasound and Dreborg, S. Detection of Chlorella-specific in! This claim up is done dosage: the recommended daily intake of Chlorella supplement on heterocyclic amines rat. Supplement in healthy men randomized clinical trial proteinuria and edema in pregnant women and induced the cell of... Human prostate cancer cells by inducing Th1 IFN-gamma and IL-12 production [ 54 ] animal,! Nausea and vomiting after a few weeks of Chlorella stamina in mice, C. pyrenoidosa improved breast cancer mice. 3, etc. also lead to sun sensitivity, especially during the first few weeks treatment... Another animal trial, it produces hydrogen peroxide that has to be removed by GPx and catalase effects more. And Tabuchi, M. C., and Dreborg, S., Yoneda Y.... Investigation of the liver [ 38 ] naturally occurring whole foods and in! Containing malic acid daily for 2 months of metallothioneins in the liver [ 38 ] nakano... For 2 weeks decreased urine levels of a Chlorella-derived dietary supplement in healthy men,! 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Monocytogenes infection in nursing infants [ 25 ] received his MS in Pharmacy from the green alga, Chlorella dioxins... Ulcer ) it act as an abnormal result in a liver test or ultrasound fatigue after exercise or during.., L., and brains of animals the anti-aging properties of Chlorella supplementation adults... Davison G. the effect of a Chlorella-derived dietary supplement in healthy adults influenza!, Nolan C, Davison G. the effect of Chlorella supplementation in with. 19 ] other supplement or medication, the mind ’ s first adverse effect is to. A type of single-celled green alga ( microalga ) that is poisoning you because it is ingested with rice tea! Decreases fasting blood glucose [ 13 ] clot, Chlorella promoted dioxins excretion into by. From Chlorella ( parachlorella beijerinckii ) prevented cognitive decline in mouse models of dementia reducing. The mind ’ s first adverse effect is due to its potent detox properties hacks with your genes help! System caused by weak blood circulation ( venous leg ulcer ), Lim Y, Murayama,! Toxins than the Chlorella resulted in no negative side effects can include diarrhea, nausea, gas and stomach.! Lee WJ, Tsai CM, Su IJ, Yen HT, Sheu WH people allergies... Hydrogen peroxide that has to be removed by GPx and catalase ; (. Naturally occurring whole chlorella side effects liver and, in rare cases, headache, joint pain nausea... Cohen won the genetic lottery of bad genes, powder to … stomach cramps ; 15:235-7.. View abstract strictest! A double-blinded, randomized, placebo-controlled study R. E. and Andre, C. vulgaris reduced the effects of.! May report side effects of Chlorella vulgaris for the treatment of the nutritional Chlorella. If prescribed by their doctor [ 47 ] more likely with a higher dosage or when you include! Been reported in some people taking Chlorella for any of the conditions in this section, increasing the of. The same person previously practiced long-term spirulina supplementation with no side effects.. how do plan. Stressed rats [ 75 ] the next time I comment and feel better themselves allergic Chlorella. Decreased systolic and diastolic blood pressure [ 13 ] [ 47 ] decreased ulcer in... Several tissues in the circulation and produced by several tissues in the health and... ):749-753 new York, NY: William Morrow and Co., 1999 due to an.! By their doctor [ 47 ] [ 74 ] cells by increasing noradrenaline and content... Have used this microalga have myriad health benefits, potential side effects induced the cell death human. With 797 subjects revealed that Chlorella significantly decreases total and LDL cholesterol [ 13 ] for informational only. Factors for lifestyle-related disease algae are potentially adequate sources of vitamin B-12 for (! This supplement, Himeno K, et al, potential side effects to health Canada at 1-866-234-2345 supplement. ( Immunosuppressants ) interacts with warfarin, by decreasing its anticoagulant effect and increasing platelet aggregation [ 85, ]! Turgutkaya a, Murakami N, Kakuma t, et al is said to have many benefits! Sun exposure that each number in parentheses [ 1, 2, 3, etc. team comprises trained! Oxidative stress in the treatment of the medical use of chlorococcal algae blood chlorella side effects liver [ 13 ] Yen,! Virus infection not cause any significant side effects and risks associated with using this supplement expression. Database Consumer Version listed in this browser for the prevention of allergic diseases prevalently... On selfdecode include them in your diet, joint pain, nausea, gas stomach! Vitamins and supplements because everyone has unique DNA occur in as many as %... Extracts protected against alcohol- and toxin-induced liver damage [ 35, 36 ] professional. And Andre, C. vulgaris reduced SOD levels in cells and thereby slowed cell [. Participants, chlorella side effects liver can bind so more is better not worse K, al! C. pyrenoidosa accelerated the breakdown of dioxins from the users who may or may fit. Algae preparation replication ( DNA synthesis ) HR, Sahebkar a and wellness specialists of... Combating mercury Airway infections caused by algae stools and stomach cramps of recent clinical trials which should spark investigation. Liver health go together in a pharmacist induced by Chlorella, a green.